Monique Verschuren Jolanda M. HbA1c concentrations were measured in erythrocytes using an immunoturbidimetric latex test. We assumed that the missing data were at random. Beulens Find articles by Joline W. Participants were recruited in both studies from to During a mean follow-up of 9.
Data analysis Participant characteristics are presented as means with SDs or percentages. Height and weight were measured, and BMI was calculated. The confounders that were entered into the model were age, sex, waist-to-hip ratio, and Cambridge physical activity index CPAI model 1. We generalized 10 imputed datasets and used Rubin rules to combine the estimates of the parameters All diagnoses were coded according to the ICD Level of education was categorized as low primary education up to those completing advanced elementary education , average intermediate vocational education and higher general secondary education or high higher vocational education and university. The Prospect-EPIC study includes 17, women 49—70 years of age living in Utrecht and vicinity who participated in the nationwide Dutch breast cancer screening program between and MGP exists as various species, which differ in their state of phosphorylation or carboxylation: Time since diabetes diagnosis was calculated by subtracting the age of diagnosis from the age at baseline examination. Find articles by Elke J. Monique Verschuren Find articles by W. In line with these results, several studies indeed showed that high dp-ucMGP levels were associated with more calcification, though not consistently 13 , 16 , 18 , Beulens Find articles by Joline W. Details of the ascertainment sources and verification procedures have previously been described Variables selected this way were incorporated into a multivariate model by means of a stepwise selection approach. Coronary artery calcification is an independent predictor of cardiovascular disease CVD 1. Potential cases of diabetes ascertained by these sources were verified against medical and pharmacy records. HbA1c concentrations were measured in erythrocytes using an immunoturbidimetric latex test. For handling missing data for confounders, we used multiple imputations. At baseline, participants were verified to have type 2 diabetes. After full adjustment, the association attenuated to nonsignificant HRSD 1. These effects are thought to be mediated by increased activation of MGP The possibility of a nonlinear relation was examined nonparametrically with restricted cubic splines 32 , and no evidence for nonlinear associations was found. Matrix Gla protein MGP is a vitamin K—dependent protein and a potent inhibitor of vascular calcification 2. This article has been cited by other articles in PMC.
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